Designed and constructed between 1940 –1941, this historic post office building, now 81 years old, is one of a number of post offices in New York State, designed by the Office of the Supervising Architect of the Treasury Department, Louis A. Simon (1867-1958). Simon began working at OSA in 1896 and retired in 1941. Most of Simon's buildings, notably post-office buildings, were designed in the Colonial Revival style. The Clyde Post Office building is a 11⁄2-story steel-framed, brick building on a raised foundation with a limestone watercourse.

The interior of the Clyde Post Office showcases a mural titled “Apple Pickers” painted in 1941 by Thomas Donnelly (1893-1971). Made possible by the Treasury Department’s Section of Fine Arts, this mural is one of hundreds commissioned by the US government during the Great Depression depicting contemporary life and local history installed in public places across the country – including many post offices. The “Apple Pickers” mural is housed in the archives of the Smithsonian American Art Museum.